ROLE OF GROWTH HORMONE IN THE BODY

Growth hormone (GH) plays a key role in an individual’s metabolism and their ability to adapt to metabolic changes within the body (known as “metabolic flexibility”). As a far-reaching signaling molecule, growth hormone has impact on many processes such as:

  • Physical/sport performance
  • Lean body mass
  • Bone density
  • Energy usage
  • Weight management and body composition
  • Deep wave sleep
  • Memory and cognition
  • Recovery from exercise and injury (connective tissue repair)
  • Immune function

As we age or we experience an illness, our natural production of growth hormone declines. Declining levels of growth hormone reduces the body’s metabolic flexibility and normal metabolism is interrupted. This can result in reduced physical stamina or performance, decreased muscle mass, poor energy or body composition, reduced sleep quality and cognitive health, poor recovery from exercise/injury, and decreased immunity.

Growth Hormone – Peptide Support

A number of peptides are now available to support growth hormone production by stimulating the pituitary gland (found at the base of the brain) to signal the increased production/release of growth hormone by the body. GH peptides are meant to supplement an individual’s natural growth hormone levels.

Combination GH-peptide therapy: Ipamorelin with CJC 1295

When these 2 peptides are combined, they cause 5x the benefits of using either Ipamorelin or CJC 1295 alone. By working synergistically, they increase the effect of growth hormone production and release by working on different receptors and mechanisms of action.

Ipamorelin

  • A synthetic pentapeptide (made of 5 amino acids).
  • Its sequence is: Aib-His-D-2-Nal-D-Phe-Lys-NH2
  • Its molecular formula is: C38H49N9O5

CJC –1295

  • A synthetic peptide made of 30 amino acids
  • Its sequence is: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala- Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys
  • Its molecular formula is: C165H269N47O46

AOD 9604

Anti-Obesity Drug (AOD 9604)

  • AOD 9604 is a modified fragment of human growth hormone, specifically the sequence that directs fat metabolism.
  • AOD 904 stimulates lipolysis (the process of breaking down fat) in adipocytes (fat cells).
  • It also inhibits lipogenesis (the creation of triglycerides- the main component of body fat in humans).
  • Together, these two actions result in fat-reducing properties.

AOD-9604 is FDA approved under the GRAS (Generally Recognized As Safe) program. This program designates food additives as safe under the Federal Food Drug and Cosmetic Act.

AOD 9604

  • A synthetic peptide made of 14 amino acids – it is the peptide fragment of the C-terminus of human growth hormone (Tyr-hGH177-191).
  • Its sequence is: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
  • Its molecular formula is: C78H123N23O23S2